Provides guidance intended to address concerns about the risk for Zika virus infection in K–12 schools in the continental United States and Hawaii, provide school districts with information for planning school-related activities, and recommend actions that can be taken, in consultation with local public health authorities and government officials, to reduce the potential risk for Zika virus transmission on school premises and among students. This guidance provides an overview of the potential roles and responsibilities of public health authorities and school officials, describes prevention measures that schools can take to reduce mosquito exposure, and provides information on responding to a case of travel-associated Zika virus infection or confirmed local mosquito-borne transmission of Zika virus. Considerations for child care, camp, and higher education settings also are addressed.